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TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition

Authors: CG Goh, A Bader, T-A Tran, R Belotserkovskaya, G D'Alessandro, S Jackson
E-pub date: 11 Jan 2025
Journal name: Nucleic Acids Research

KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency.

Authors: SW Awwad, C Doyle, J Coulthard, AS Bader, N Gueorguieva, S Lam, V Gupta, R ...
E-pub date: 8 Jan 2025
Journal name: Nature Communications

Selective Photocatalytic C-H Oxidation of 5-Methylcytosine in DNA.

Authors: T Yan, Y Chen, B Mortishire-Smith, A Simeone, A Hofer, S Balasubramanian
E-pub date: 2 Jan 2025
Journal name: Angew Chem Int Ed Engl

Insights from the bottom-up development of LGR5-targeting immunotherapeutics.

Authors: N Mueller, MA de la Roche, M de la Roche
E-pub date: 30 Dec 2024
Journal name: Immunotherapy Advances

ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer.

Authors: B DiCiaccio, M Seehawer, Z Li, A Patmanidis, T Bui, P Foidart, J Nishida, C...
E-pub date: 24 Dec 2024
Journal name: Cell Rep

The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer.

Authors: Z Li, F Chen, L Chen, J Liu, D Tseng, F Hadi, S Omarjee, K Kishore, J Kent,...
E-pub date: 19 Dec 2024
Journal name: NPJ Breast Cancer

AAV-mediated genome editing is influenced by the formation of R-loops.

Authors: F Puzzo, MP Crossley, A Goswami, F Zhang, K Pekrun, JL Garzon, KA Cimprich,...
E-pub date: 4 Dec 2024
Journal name: Mol Ther

Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer

Authors: L Veghini, D Pasini, R Fang, P Delfino, D Filippini, C Neander, C Vicentini...
E-pub date: 3 Dec 2024
Journal name: Nat Commun