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A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency.

Authors: S Lukasiak, A Kalinka, N Gupta, A Papadopoulos, K Saeed, U McDermott, GJ Ha...
Research group: Hannon Group
E-pub date: 26 Feb 2025
Journal name: BMC Genomics

Promoting equitable genetic testing in ovarian cancer: the demonstration of improvement for molecular ovarian cancer testing (DEMO) project.

Authors: EY Leung, IG Funingana, L Bird, M-L Alcaraz, A Evans, A Considine, S Freema...
Research group: Brenton Group
E-pub date: 25 Feb 2025
Journal name: BMJ Open Qual

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures.

Authors: L Morrill Gavarró, D-L Couturier, F Markowetz
Research group: Markowetz Group
E-pub date: 18 Feb 2025
Journal name: BMC Bioinformatics

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance.

Authors: IJJ Muffels, HR Waterham, G D'Alessandro, G Zagnoli-Vieira, M Sacher, DJ Le...
Research group: Jackson Group
E-pub date: 7 Feb 2025
Journal name: Genome Med

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Authors: P Wijnhoven, R Konietzny, AN Blackford, J Travers, BM Kessler, R Nishi, SP ...
Research group: Jackson Group
E-pub date: 6 Feb 2025
Journal name: Mol Cell

Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation.

Authors: T Whitmarsh, W Cope, J Carmona-Bozo, R Manavaki, S-J Sammut, R Woitek, E Pr...
Research group: Markowetz Group, Bohndiek Group
E-pub date: 4 Feb 2025
Journal name: Breast Cancer Res

Transcriptional regulation of the piRNA pathway by Ovo in animal ovarian germ cells.

Authors: A Alizada, GJ Hannon, BC Nicholson
Research group: Hannon Group
E-pub date: 3 Feb 2025
Journal name: Genes Dev

The need for evidence-based, outcome-focused medical imaging research for cancer management.

Authors: J Wang, RL Hesketh, JC Gore, KM Brindle
Research group: Brindle Group
E-pub date: 3 Feb 2025
Journal name: Npj Imaging