Wang Group
Spatial genomics of cancer
Research summary
The behaviour of a cancer cell is defined by both its DNA and how that DNA, along with the cell’s RNAs and proteins, is organised in space inside the cell. Our group applies and invents new imaging and epigenomic sequencing approaches to measure these changes inside individual cancer cells, with the aim of finding new weaknesses that can be targeted by treatments.
Overview
The Wang group develops and applies imaging and epigenomic sequencing methods to study cancer at multiple scales: from the spatial organisation of molecules within a single cell to the genome-wide circuits that drive disease.
By engineering new tools to quantify genome organisation, chromatin states, and gene expression inside single cells, we aim to build a quantitative, multi-scale picture of how cancer cells rewire these molecular layers and how the resulting vulnerabilities can be exploited therapeutically.
Dr Guiping Wang
Junior Group Leader
Areas of interest
Spatial multi-omics technology
Building scalable spatial and single-cell methods to read multiple molecular layers of genome regulation in their native cellular and tissue context.
Extrachromosomal DNA biology
Investigating how ecDNA drives oncogene overexpression, tumour plasticity and therapy resistance in aggressive cancers.
Therapeutic vulnerabilities
Selected Publications
We are hiring
The Wang Group is currently recruiting a PhD student for the project “Single-cell spatial multi-omics for cancer biology”.
Apply now