Senior Scientific Associate (Fixed Term)

Join the Crossley Research Group at the Cancer Research UK Cambridge Institute, where we investigate RNA-DNA hybrid molecules known as R-loops and their role in human disease. Our research focuses on understanding how R-loops contribute to genome instability and inflammation, and how these molecules and the cellular responses they trigger can be harnessed for cancer detection and treatment. To learn more about the group, visit: https://www.cruk.cam.ac.uk/research-groups/crossley-group/

We are looking for an experienced, scientifically driven and collaborative researcher to join our growing team. This role combines hands-on experimental research with opportunities to contribute to scientific support activities and laboratory operations. You will work closely with colleagues to advance projects through to publication, help establish new research directions and methodologies, and, if desired, take the lead on your own projects. You will also partner with our Senior Scientific Associate, Dr Mawer, to support the day-to-day management and smooth running of the laboratory.

What You'll Be Doing

Working across a range of cutting-edge research projects, you will use techniques including:

• Molecular biology, such as cloning, western blotting, human cell culture, CRISPR/Cas gene editing, lentiviral infection and qPCR.

• RNA and nucleic acid biochemistry, including RNA/DNA and RNA-DNA hybrid isolation, immunoprecipitations and pull-down assays.

• Immunofluorescence microscopy and flow cytometry.

• Genomics approaches, including next-generation sequencing (NGS) library preparation and bioinformatics analysis.

About You

We are particularly interested in candidates with strong molecular biology and biochemistry expertise, alongside experience in mammalian cell and/or tissue culture. You should have in-depth knowledge in at least one of the following areas:

• Genome stability

• RNA biology

• Chromatin biology

• Innate immunity

• Cancer biology

Experience with next-generation sequencing and/or bioinformatics would be advantageous but is not essential.

Beyond technical expertise, we are seeking someone who enjoys working collaboratively, both within the group and with external partners. You should be organised, detail-oriented and committed to maintaining high standards of data management, record keeping and laboratory practice. A proactive, positive approach to problem-solving and a willingness to support colleagues are highly valued.

With significant long-term funding recently secured, this is an exciting opportunity to join and help shape a growing research group at an important stage of its development.

Fixed-term: The funds for this post are available for 18 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 15th September 2026

The interview date for the role is: To be Confirmed

Please quote reference SW50858 on your application and in any correspondence about this vacancy.

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