Research Assistant (Gilbertson Group) (Fixed Term)

We are seeking a motivated and skilled in vivo Research Assistant to join the group of Professor Richard Gilbertson at the Cancer Research UK Cambridge Institute. The Gilbertson lab is dedicated to understanding the origins and progression of paediatric brain tumours and developing new therapeutic strategies. The lab combines genetic engineering, molecular biology, and translational research to investigate the cellular and molecular mechanisms driving tumour development.

In this role, you will support Dr Cooper, using genetically engineered mouse models (GEMMs) and transplantable tumour models (e.g., immunocompetent orthotopic allotransplantation models) to study the role of the immune system in tumour biology and therapeutic response. You will play a key role in immunophenotyping a broad array of tissues across our spontaneous mouse models, following functional perturbation experiments in vivo or ex vivo, as well as working collaboratively with postdoctoral researchers, students, and other research staff in the group.

Key responsibilities will include:

Conducting detailed necropsies and dissociation of mouse tissues for downstream flow cytometry and molecular analysis

Perform spectral flow cytometry on mouse tissues and downstream analysis

Performing cell culture and in vitro immune cell assays

Performing high-plex immunohistochemical staining of mouse and human tissue

Conduct confocal imaging of immunofluorescent staining of mouse tissues

Conducting detailed necropsies and tissue dissections for downstream molecular analyses

Maintaining accurate and organised records of experimental studies and ensure data is captured in lab databases

Complying with all regulatory requirements including Home Office licences, local AWERB oversight, and institutional biosafety and welfare protocols

The successful candidate will hold a B.Sc. or M.Sc. in a relevant discipline (e.g., Biomedical Sciences, Immunology, Oncology, or Neuroscience), and a Home Office Personal Licence (Modules A, B and C or equivalent).

They should have demonstrable experience in a range of in vitro and ex vivo techniques, including flow cytometry, cell culture, immunohistochemistry and immunofluorescence staining. Proficiency in performing mouse necropsies is preferred, but not essential.

The ideal candidate will be proactive, adaptable, and capable of working effectively under pressure, with excellent communication skills and a strong focus on teamwork and accurate data recording.

This position offers the opportunity to contribute directly to impactful cancer research in a dynamic and supportive team.

Fixed-term: The funds for this post are available for 18 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries may be made to Elizabeth.cooper@cruk.cam.ac.uk

Please quote reference SW48729 on your application and in any correspondence about this vacancy.

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