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Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta.

Abstract:
Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with a call to provide solutions to visualize tumor heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging to map tumor heterogeneity at the cellular and molecular scales with different levels of resolution. See related article by Bressan et al., p. 16 See related article by Stratton et al., p. 22 See related article by Bhattacharjee et al., p. 28.
Authors:
RJA Goodwin, Cancer Grand Challenges Rosetta Consortium, JF Marshall, G Poulogiannis, M Yuneva, KM Brindle, Z Takáts, OJ Sansom, J Bunch, ST Barry, Cancer Grand Challenges Rosetta Consortium
Journal:
Cancer Discov
Citation info:
15(1):34-38
Publication date:
13th Jan 2025
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DOI