Transmitting senescence to the cell neighbourhood.

Abstract:

Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.

Authors:

M Hoare, M Narita

Journal:

Nat Cell Biol

Citation info:

15(8):887-889

Publication date:

31st Aug 2013

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