Translating the effects of mTOR on secretory senescence.

Abstract:

Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.

Authors:

K Tomimatsu, M Narita

Journal:

Nat Cell Biol

Citation info:

17(10):1230-1232

Publication date:

1st Oct 2015

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