The Mre11 complex: at the crossroads of dna repair and checkpoint signalling.

Abstract:

The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA-damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.

Authors:

D D'Amours, SP Jackson

Journal:

Nature Reviews Molecular Cell Biology

Citation info:

3(5):317-327

Publication date:

22nd Jun 2002

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