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The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

Abstract:
Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that considered the methodology and design of magnetic resonance studies, recommending how this new tool might best be used.
Authors:
MO Leach, KM Brindle, JL Evelhoch, JR Griffiths, MR Horsman, A Jackson, GC Jayson, IR Judson, MV Knopp, RJ Maxwell, D McIntyre, AR Padhani, P Price, R Rathbone, GJ Rustin, PS Tofts, GM Tozer, W Vennart, JC Waterton, SR Williams, P Workman, Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee, Drug Development Office, Cancer Research UK
Journal:
Br J Cancer
Citation info:
92(9):1599-1610
Publication date:
9th May 2005
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