Solid-phase synthesis of N-alkyl-N-(beta-keto)amides and 1,2,4,5-tetrasubstituted imidazoles using a traceless cleavage strategy.
- Abstract:
- [reaction: see text] The solid-phase synthesis of N-alkyl-beta-keto)amides and 1,2,4,5-tetrasubstituted imidazoles was demonstrated using a traceless cleavage strategy based on benzylic acylammonium chloride reactivity. The approach enables the assembly of diverse compounds in a minimal number of steps in moderate to excellent yield (23-88%) and high purity (64-100%).
- Authors:
- HB Lee, S Balasubramanian
- Journal:
- Org Lett
- Citation info:
- 2(3):323-326
- Publication date:
- 10th Feb 2000
- Full text
- DOI