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Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.

Abstract:
The aim of this study was to assess the feasibility of rapid sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relationship of 23Na-MRI with tumour cellularity. 23Na-MRI was performed at 3 T on twelve HGSOC patients using a 3D-cones acquisition technique. Tumour biopsies specimens were collected after imaging and cellularity was measured from histology. Total 23Na-MRI scan time for each patient was approximately 11 min. At an isotropic resolution of 5.6 mm, signal-to-noise ratios (SNRs) of 82.2 ± 15.3 and 15.1 ± 7.1 (mean ± standard deviation) were achieved for imaging of tumour tissue sodium concentration (TSC) and intracellular weighted sodium concentration (IWS) respectively. Tumour TSC and IWS concentrations were: 56.8 ± 19.1 mM and 30.8 ± 9.2 mM respectively and skeletal muscle TSC and IWS concentrations were 33.2 ± 16.3 mM and 20.5 ± 9.9 mM respectively. There were significant sodium concentration differences between cancer and skeletal muscle, Wilcoxon signed-rank test, P 
Authors:
SS Deen, F Riemer, MA McLean, AB Gill, JD Kaggie, JT Grist, R Crawford, J Latimer, P Baldwin, HM Earl, CA Parkinson, SA Smith, C Hodgkin, E Moore, M Jimenez-Linan, CR Brodie, HC Addley, SJ Freeman, PL Moyle, E Sala, MJ Graves, JD Brenton, FA Gallagher
Journal:
Eur J Radiol Open
Citation info:
6:156-162
Publication date:
1st Aug 2019
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