Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

Abstract:

Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.

Authors:

A Bugaut, R Rodriguez, S Kumari, S-TD Hsu, S Balasubramanian

Journal:

Org Biomol Chem

Citation info:

8(12):2771-2776

Publication date:

21st Jun 2010

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