Site-specific cleavage of human telomerase RNA using PNA-neocuproine.Zn(II) derivatives.

Abstract:

Here we report the synthesis of a novel PNA based neocuproine.Zn RNA cleaving agent; we demonstrate that such agents sequence specifically cleave a synthetic RNA target and in particular the RNA component of human telomerase.

Authors:

A Whitney, G Gavory, S Balasubramanian

Journal:

Chem Commun (Camb)

Citation info:

(1):36-37

Publication date:

7th Jan 2003

Full text

DOI