Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

Abstract:

It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.

Authors:

M Di Antonio, G Biffi, A Mariani, E-A Raiber, R Rodriguez, S Balasubramanian

Journal:

Angew Chem Int Ed Engl

Citation info:

51(44):11073-11078

Publication date:

29th Oct 2012

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