RNA interference.

Abstract:

A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.

Authors:

GJ Hannon

Journal:

Nature

Citation info:

418(6894):244-251

Publication date:

11th Jul 2002

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