RNA interference in adult mice.

Abstract:

RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

Authors:

AP McCaffrey, L Meuse, T-TT Pham, DS Conklin, GJ Hannon, MA Kay

Journal:

Nature

Citation info:

418(6893):38-39

Publication date:

4th Jul 2002

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