Rapid diagnosis of medulloblastoma molecular subgroups.

Abstract:: PURPOSE: Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management. EXPERIMENTAL DESIGN: Minimal mRNA expression signatures diagnostic for the Wnt/Wingless (WNT) and Sonic Hedgehog (SHH) subgroups were developed, validated, and used to assign subgroup affiliation in 173 tumors from four independent cohorts, alongside a systematic investigation of subgroup clinical and molecular characteristics. RESULTS: WNT tumors [12% (21/173)] were diagnosed >5 years of age (peak, 10 years), displayed classic histology, CTNNB1 mutation (19/20), and associated chromosome 6 loss, and have previously been associated with favorable prognosis. SHH cases [24% (42/173)] predominated in infants (

Authors:: EC Schwalbe, JC Lindsey, D Straughton, TL Hogg, M Cole, H Megahed, SL Ryan, ME Lusher, MD Taylor, RJ Gilbertson, DW Ellison, S Bailey, SC Clifford

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