Quality and quantity control of proteins in senescence.

Abstract:

Autophagy has been implicated in aging and age-related diseases but its roles in these processes are far from straightforward: the anti-aging effect of autophagy has been shown in lower eukaryotes, and both pro- and anti-tumorigenic effects of autophagy have also been demonstrated. The new link between autophagy and senescence provides an insight into the diversified downstream effects of autophagy in various cellular contexts.

Authors:

M Narita

Journal:

Aging (Albany NY)

Citation info:

2(5):311-314

Publication date:

1st May 2010

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