Putting the DOT on IL1A.

Abstract:

IL-1α is an upstream component of the senescence-associated secretory phenotype. In this issue, Leon et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202008101) show that DOT1L-mediated H3K79 methylation at the IL1A gene plays a key role in its induction during oncogene-induced senescence.

Authors:

I Olan, M Narita

Journal:

J Cell Biol

Citation info:

220(8)

Publication date:

2nd Aug 2021

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