Polyclonal origin of mouse skin papillomas.
- Abstract:
- We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation chimaeras, a method which removes some of the uncertainties of previous conclusions based on analysis using electrophoretic polymorphisms. The findings may imply that initiation within a single cell and promotion of its clonal descendents is not a sufficient explanation for the origin of these tumours and that interaction between cells of more than one clone is involved.
- Authors:
- DJ Winton, MA Blount, BA Ponder
- Journal:
- Br J Cancer
- Citation info:
- 60(1):59-63
- Publication date:
- 1st Jul 1989
- Full text
- DOI