Peroxide-cleavable linkers for antibody-drug conjugates.

Abstract:

Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro.

Authors:

N Ashman, JD Bargh, SJ Walsh, RD Greenwood, A Tiberghien, JS Carroll, DR Spring

Journal:

Chem Commun (Camb)

Citation info:

59(13):1841-1844

Publication date:

9th Feb 2023

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