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Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.
Authors:
Research group: Brenton Group, Narita Group
E-pub date: 1 Feb 2026
Journal name: Nat Aging

ICON8B: GCIG phase III randomised trial comparing first-line weekly dose-dense chemotherapy + bevacizumab to three-weekly chemotherapy + bevacizumab in high-risk stage III-IV epithelial ovarian cancer: final overall survival (OS) analysis
Authors: A Clamp, I Mcneish, D Radice, R Lord, A Michael, A Cook, R Agarwal, A Walth...
Research group: Brenton Group
E-pub date: 1 Feb 2026
Journal name: International Journal of Gynecological Cancer

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Authors: AM Vaquié, DR Shah, EES Brechbühl, M McNicholas, Z Xu, JH Stockley, L Mor...
Research group: Brindle Group
E-pub date: 1 Feb 2026
Journal name: Mol Oncol

Optical coherence tomography and elastography for ex vivo visualization of early gastric cancer.
Authors: AG Gonzales, C Ruhland, G Spicer, S Mead, M Di Pietro, A Sanduka, PFS Rice,...
Research group: Bohndiek Group
E-pub date: 1 Feb 2026
Journal name: J Biomed Opt

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay.
Authors: SH Hough, SS Jhujh, SW Awwad, OE Lewis, S Lam, JC Thomas, T Mosler, A Bader...
Research group: Jackson Group
E-pub date: 1 Feb 2026
Journal name: EMBO Mol Med

MDC1 counteracts replication fork reversal and mediates chemosensitivity in BRCA1/2-deficient tumors.
Authors: H Dogan, M Liptay, JS Barbosa, E Gogola, AA Duarte, JA Schmid, I Klebic, M ...
Research group: Jackson Group
E-pub date: 1 Feb 2026
Journal name: Oncogene

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer.
Authors: F Puddu, A Johansson, A Modat, J Scotcher, R Sethi, S Yu, N Harding, M Hill...
Research group: Balasubramanian Group
E-pub date: 20 Jan 2026
Journal name: Commun Med (Lond)

CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance.
Authors: A Watterson, G Picco, V Veninga, Y Samarakoon, CM Cattaneo, SF Vieira, E Ka...
Research group: Halim Group
E-pub date: 20 Jan 2026
Journal name: Cell Rep Med