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1P Whole-genome sequencing (WGS) measures of theta-mediated end joining (TMEJ) predict PARP inhibitors (PARPi) benefit

Authors: IG Funingana, J Ambrose, P Smith, T Bradley, L Porcu, AA Sosinsky, JD Brent...
Research group: Brenton Group
E-pub date: 1 Jun 2025
Journal name: ESMO Open

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.

Authors: Z Li, G Peluffo, LE Stevens, X Qiu, M Seehawer, A Tawawalla, X-Y Huang, SB ...
Research group: Carroll Group
E-pub date: 1 Jun 2025
Journal name: Nat Genet

CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer.

Authors: M Waterhouse, K Lazarus, MF Santolla, S Pensa, E Williams, AJQ Siu, H Moham...
Research group: Carroll Group
E-pub date: 1 Jun 2025
Journal name: EMBO J

Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch.

Authors: X Zhang, S Dhir, L Melidis, Y Chen, Z Yu, A Simeone, J Spiegel, S Adhikari,...
Research group: Balasubramanian Group
E-pub date: 1 Jun 2025
Journal name: Nat Chem

A photoswitchable DNA G-quadruplex ligand enables optical control of transcription.

Authors:
Research group: Balasubramanian Group
E-pub date: 1 Jun 2025
Journal name: Nat Chem

Spatial invasion patterns of temporal lobe glioblastoma after complete resection of contrast-enhancing tumor.

Authors: J Fares, Y Wan, B Gurung, T Nazar, R Mair, A Joannides, T Santarius, T Maty...
Research group: Mair Group
E-pub date: 1 Jun 2025
Journal name: J Neurooncol

Analysis of event-free survival (EFS) of stromal tumor infiltrating lymphocytes (sTILs), PD-L1 expression, and their early dynamics in the NeoTRIP trial.

Authors: G Bianchini, G Viale, M Dugo, C-S Huang, D Egle, M Callari, H Ali, B Bermej...
Research group: Ali Group
E-pub date: 1 Jun 2025
Journal name: Journal of Clinical Oncology

Why do we continue to have an incomplete understanding of estrogen receptor(s) actions in cancer systems?

Authors: HD McMillan, JS Carroll
Research group: Carroll Group
E-pub date: 1 Jun 2025
Journal name: Endocr Relat Cancer