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A randomized, placebo-controlled phase II trial comparing gemcitabine monotherapy to gemcitabine in combination with AZD 1775 (MK 1775) in women with recurrent, platinum-resistant epithelial ovarian, primary peritoneal, or Fallopian tube cancers: Trial of Princess Margaret, Mayo, Chicago, and California consortia.

Authors: S Lheureux, JI Weberpals, AEW Hendrickson, GF Fleming, A Olawaiye, I Brana,...
E-pub date: 20 May 2015
Journal name: Journal of Clinical Oncology

Assessment of clinical applications of circulating tumor DNA using an enhanced TAm-Seq platform.

Authors: V Plagnol, A Lawson, T Forshew, A Fahem, J Brenton, D Gale, N Rosenfeld
E-pub date: 20 May 2015
Journal name: Journal of Clinical Oncology

Results of ARIEL2: A Phase 2 trial to prospectively identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis.

Authors: IA McNeish, AM Oza, RL Coleman, CL Scott, GE Konecny, A Tinker, DM O'Malley...
E-pub date: 20 May 2015
Journal name: Journal of Clinical Oncology

An epigenetic memory of pregnancy in the mouse mammary gland.

Authors: CO Dos Santos, E Dolzhenko, E Hodges, AD Smith, GJ Hannon
E-pub date: 19 May 2015
Journal name: Cell Reports

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

Authors: WSS Goh, I Falciatori, OH Tam, R Burgess, O Meikar, N Kotaja, M Hammell, GJ...
E-pub date: 15 May 2015
Journal name: Genes Dev

Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.

Authors: Y Tong, D Merino, B Nimmervoll, K Gupta, Y-D Wang, D Finkelstein, J Dalton,...
E-pub date: 11 May 2015
Journal name: Cancer Cell

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

Authors: KW Pajtler, H Witt, M Sill, DTW Jones, V Hovestadt, F Kratochwil, K Wani, R...
E-pub date: 11 May 2015
Journal name: Cancer Cell

G-quadruplex ligands exhibit differential G-tetrad selectivity.

Authors: DD Le, M Di Antonio, LKM Chan, S Balasubramanian
E-pub date: 11 May 2015
Journal name: Chem Commun (Camb)