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A NOTCH1-DRIVEN SECRETOME SWITCH MODULATES IMMUNE SURVEILLANCE IN RAS-INDUCED SENESCENCE
Authors: M Hoare, Y Ito, T-W Kang, S Menon, R Salama, L Zender, M Narita
E-pub date: 1 Jun 2016
Journal name: Gut
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.
Authors: CL Sutherell, C Tallant, OP Monteiro, C Yapp, JE Fuchs, O Fedorov, P Siejka...
E-pub date: 26 May 2016
Journal name: J Med Chem
CALIBRATE: Intensive profiling of circulating tumour DNA (ctDNA) from patients participating in experimental therapeutics trials including mutational profiles and copy number changes.
Authors: J Garcia-Corbacho, F Mouliere, H Carr, JA Morris, F Marrass, DG Gale, S Kum...
E-pub date: 20 May 2016
Journal name:
Circulating tumour DNA carrying patient-specific mutations in TP53 as an early response biomarker in relapsed high grade serous ovarian cancer.
Authors: CA Parkinson, D Gale, A Piskorz, C Hodgkin, H Biggs, H Addley, P Moyle, S F...
E-pub date: 20 May 2016
Journal name: Journal of Clinical Oncology
PISARRO: A EUTROC phase Ib study of APR-246 in combination with carboplatin (C) and pegylated liposomal doxorubicin (PLD) in platinum sensitive relapsed high grade serous ovarian cancer (HGSOC).
Authors: C Gourley, J Green, H Gabra, I Vergote, B Basu, JD Brenton, U Bjorklund, AM...
E-pub date: 20 May 2016
Journal name: Journal of Clinical Oncology
Refinement of prespecified cutoff for genomic loss of heterozygosity (LOH) in ARIEL2 part 1: A phase II study of rucaparib in patients (pts) with high grade ovarian carcinoma (HGOC).
Authors: RL Coleman, EM Swisher, AM Oza, CL Scott, H Giordano, KK Lin, GE Konecny, A...
E-pub date: 20 May 2016
Journal name: Journal of Clinical Oncology
Feasibility of monitoring response to the PARP inhibitor rucaparib with targeted deep sequencing of circulating tumor DNA (ctDNA) in women with high-grade serous carcinoma on the ARIEL2 trial.
Authors: A Piskorz, KK Lin, JA Morris, E Mann, AM Oza, RL Coleman, DM O'Malley, M Fr...
E-pub date: 20 May 2016
Journal name: Journal of Clinical Oncology
Evaluation of liquid biopsies for molecular profiling and monitoring in non-small cell lung cancer (NSCLC) patients.
Authors: J Remon, J-C Soria, L Lacroix, K Howarth, A Lawson, S Smalley, D Gale, V Pl...
E-pub date: 20 May 2016
Journal name: Journal of Clinical Oncology