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Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.
Authors: TA Hore, F von Meyenn, M Ravichandran, M Bachman, G Ficz, D Oxley, F Santos...
E-pub date: 25 Oct 2016
Journal name: Proc Natl Acad Sci U S A

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.
Authors: DG McFadden, K Politi, A Bhutkar, FK Chen, X Song, M Pirun, PM Santiago, C ...
E-pub date: 18 Oct 2016
Journal name: Proc Natl Acad Sci U S A

Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups.
Authors: M Abubakar, N Orr, F Daley, P Coulson, HR Ali, F Blows, J Benitez, R Milne,...
E-pub date: 18 Oct 2016
Journal name: Breast Cancer Res

New paradigms for BRCA1/BRCA2 testing in women with ovarian cancer: results of the Genetic Testing in Epithelial Ovarian Cancer (GTEOC) study.
Authors: I Plaskocinska, H Shipman, J Drummond, E Thompson, V Buchanan, B Newcombe, ...
E-pub date: 1 Oct 2016
Journal name: J Med Genet

Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma.
Authors: M Köbel, AM Piskorz, S Lee, S Lui, C LePage, F Marass, N Rosenfeld, A-M Me...
E-pub date: 1 Oct 2016
Journal name: J Pathol Clin Res

PISARRO: A EUTROC phase 1b study of APR-246 with carboplatin (C) and pegylated liposomal doxorubicin (PLD) in relapsed platinum-sensitive high grade serous ovarian cancer (HGSOC)
Authors: B Basu, C Gourley, H Gabra, IB Vergote, JD Brenton, L Abrahmsen, A Smith, M...
E-pub date: 1 Oct 2016
Journal name: Annals of Oncology

G-quadruplex structures mark human regulatory chromatin.
Authors: R Hänsel-Hertsch, D Beraldi, SV Lensing, G Marsico, K Zyner, A Parry, M Di...
E-pub date: 1 Oct 2016
Journal name: Nat Genet

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.
Authors: M Secrier, X Li, N de Silva, MD Eldridge, G Contino, J Bornschein, S MacRae...
E-pub date: 1 Oct 2016
Journal name: Nat Genet