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A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome.

Authors: DZ Bar, MF Arlt, JF Brazier, WE Norris, SE Campbell, P Chines, D Larrieu, S...
E-pub date: 1 Mar 2017
Journal name: J Med Genet

BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes.

Authors: I de Santiago, W Liu, K Yuan, M O'Reilly, CSR Chilamakuri, BAJ Ponder, KB M...
E-pub date: 24 Feb 2017
Journal name: Genome Biol

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Authors: H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O'Neil, ND Santos, J Sil...
E-pub date: 17 Feb 2017
Journal name: Nat Commun

A switch from canonical to noncanonical autophagy shapes B cell responses.

Authors: N Martinez-Martin, P Maldonado, F Gasparrini, B Frederico, S Aggarwal, M Ga...
E-pub date: 10 Feb 2017
Journal name: Science

2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA.

Authors: SM Huber, P van Delft, A Tanpure, EA Miska, S Balasubramanian
E-pub date: 8 Feb 2017
Journal name: J Am Chem Soc

Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

Authors: KN Timm, D-E Hu, M Williams, AJ Wright, MI Kettunen, BWC Kennedy, TJ Larkin...
E-pub date: 3 Feb 2017
Journal name: J Biol Chem

Cancer: Double trouble for tumours.

Authors: G Biffi, DA Tuveson
E-pub date: 2 Feb 2017
Journal name: Nature

Integrated efficacy and safety analysis of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in patients (pts) with high-grade ovarian carcinoma (HGOC)

Authors: A Oaknin, A Oza, AV Tinker, I Ray-Coquard, R Coleman, D O'Malley, R Shapira...
E-pub date: 1 Feb 2017
Journal name: European Journal of Cancer