On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair.

Abstract:

Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.

Authors:

CK Schmidt, SP Jackson

Journal:

Cell

Citation info:

153(3):513-515

Publication date:

25th Apr 2013

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