miR-34a sets the “sweet spot” for notch in colorectal cancer stem cells.

Abstract:

Mechanisms underlying alternative modes of symmetric versus asymmetric stem cell fates are not well understood. In this issue of Cell Stem Cell, Bu et al. (2013) find that miR-34a acts as a toggle switch for Notch signaling that dictates binary symmetric and asymmetric fates in colon cancer stem cells.

Authors:

DJ Winton

Journal:

Cell Stem Cell

Citation info:

12(5):499-501

Publication date:

2nd May 2013

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