Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

Abstract:

In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring "normal" Cdx2-positive cells.

Authors:

FC Lourenço, DJ Winton

Journal:

J Exp Med

Citation info:

215(3):725-727

Publication date:

5th Mar 2018

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