Metadata-driven software for clinical trials
- Abstract:
- The CancerGrid approach to clinical trials information systems is based on a metamodel developed from the CONSORT statement of best practice in reporting randomised controlled trials. The metamodel is instantiated with metadata elements drawn from a repository, to create a model of a particular clinical trial. The model is then used to derive automatically a trial management system customized for that trial: generating electronic case report forms, configuring randomisation and eligibility services, and parameterising the security subsystem. The key benefits of the approach are a uniform mechanism for trial registration and discovery, reduced cost and rapid implementation of information systems, and shared semantics leading to improved opportunities for meta-analysis. We describe our implementation of this approach, and outline two applications: for a breast cancer study in the UK, and for a rheumatoid arthritis study run by the US Veterans' Health Administration. © 2009 IEEE.
- Authors:
- C Crichton, J Davies, J Gibbons, S Harris, A Tsui, J Brenton
- Journal:
- Proceedings of the 2009 ICSE Workshop on Software Engineering in Health Care, SEHC 2009
- Citation info:
- :1-11
- Publication date:
- 19th Oct 2009
- Full text
- DOI