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Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models.

Abstract:
The factors responsible for the low detection rate of cell-free tumor DNA (ctDNA) in the plasma of patients with glioblastoma (GBM) are currently unknown. In this study, we measured circulating nucleic acids in patient-derived orthotopically implanted xenograft (PDOX) models of GBM (n = 64) and show that tumor size and cell proliferation, but not the integrity of the blood-brain barrier or cell death, affect the release of ctDNA in treatment-naïve GBM PDOX. Analysis of fragment length profiles by shallow genome-wide sequencing (
Authors:
R Mair, F Mouliere, CG Smith, D Chandrananda, D Gale, F Marass, DWY Tsui, CE Massie, AJ Wright, C Watts, N Rosenfeld, KM Brindle
Journal:
Cancer Res
Citation info:
79(1):220-230
Publication date:
1st Jan 2019
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