Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.
- Abstract:
- The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
- Authors:
- P Murat, MV Gormally, D Sanders, M Di Antonio, S Balasubramanian
- Journal:
- Chem Commun (Camb)
- Citation info:
- 49(76):8453-8455
- Publication date:
- 4th Oct 2013
- Full text
- DOI