Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.
- Abstract:
- To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value
- Authors:
- EO Dareng, SG Coetzee, JP Tyrer, P-C Peng, W Rosenow, S Chen, BD Davis, FS Dezem, J-H Seo, R Nameki, AL Reyes, KKH Aben, H Anton-Culver, NN Antonenkova, G Aravantinos, EV Bandera, LE Beane Freeman, MW Beckmann, A Beeghly-Fadiel, J Benitez, MQ Bernardini, L Bjorge, A Black, NV Bogdanova, KL Bolton, JD Brenton, A Budzilowska, R Butzow, H Cai, I Campbell, R Cannioto, J Chang-Claude, SJ Chanock, K Chen, G Chenevix-Trench, AOCS Group, Y-E Chiew, LS Cook, A DeFazio, J Dennis, JA Doherty, T Dörk, A du Bois, M Dürst, DM Eccles, G Ene, PA Fasching, JM Flanagan, RT Fortner, F Fostira, A Gentry-Maharaj, GG Giles, MT Goodman, J Gronwald, CA Haiman, N Håkansson, F Heitz, MAT Hildebrandt, E Høgdall, CK Høgdall, R-Y Huang, A Jensen, ME Jones, D Kang, BY Karlan, AN Karnezis, LE Kelemen, CJ Kennedy, EK Khusnutdinova, LA Kiemeney, SK Kjaer, J Kupryjanczyk, M Labrie, D Lambrechts, MC Larson, ND Le, J Lester, L Li, J Lubiński, M Lush, JR Marks, K Matsuo, T May, JR McLaughlin, IA McNeish, U Menon, S Missmer, F Modugno, M Moffitt, AN Monteiro, KB Moysich, SA Narod, T Nguyen-Dumont, K Odunsi, H Olsson, NC Onland-Moret, SK Park, T Pejovic, JB Permuth, A Piskorz, D Prokofyeva, MJ Riggan, HA Risch, C Rodríguez-Antona, MA Rossing, DP Sandler, VW Setiawan, K Shan, H Song, MC Southey, H Steed, R Sutphen, AJ Swerdlow, SH Teo, KL Terry, PJ Thompson, LC Vestrheim Thomsen, L Titus, B Trabert, R Travis, SS Tworoger, E Valen, E Van Nieuwenhuysen, DV Edwards, RA Vierkant, PM Webb, OPAL Study Group, CR Weinberg, RM Weise, N Wentzensen, E White, SJ Winham, A Wolk, Y-L Woo, AH Wu, L Yan, D Yannoukakos, N Zeinomar, W Zheng, A Ziogas, A Berchuck, EL Goode, DG Huntsman, CL Pearce, SJ Ramus, TA Sellers, Ovarian Cancer Association Consortium (OCAC), ML Freedman, K Lawrenson, JM Schildkraut, D Hazelett, JT Plummer, S Kar, MR Jones, PDP Pharoah, SA Gayther
- Journal:
- Am J Hum Genet
- Citation info:
- 111(6):1061-1083
- Publication date:
- 6th Jun 2024
- Full text
- DOI