Inhibition of human telomerase by PNA-cationic peptide conjugates.

Abstract:

The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.

Authors:

JG Harrison, C Frier, R Laurant, R Dennis, KD Raney, S Balasubramanian

Journal:

Bioorg Med Chem Lett

Citation info:

9(9):1273-1278

Publication date:

3rd May 1999

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