In vivo hyperpolarized 129Xe NMR spectroscopy in tumors.

Abstract:: The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH-3 prolactinomas in rats and RIF-1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin-lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments.

Authors:: J Wolber, DJ McIntyre, LM Rodrigues, P Carnochan, JR Griffiths, MO Leach, A Bifone

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