Imaging response to radio-chemotherapy in glioblastoma tumor models using deuterium metabolic imaging
- Abstract:
- Metabolic imaging of brain tumor responses to radio-chemotherapy can give an early indication of treatment outcome. We show here that Deuterium Metabolic Imaging (DMI) with 2 H-labeled fumarate is more sensitive than diffusion weighted 1 H imaging (DWI) in detecting early evidence of cell death following radio-chemotherapy in orthotopically implanted patient-derived glioblastoma xenografts. 2 H spectra were acquired from tumors with a time resolution of 5min, following an injection of 2 H-labelled fumarate. Within 48h after the last chemo-radiotherapy treatment (CRT) the rate of tumor malate production from labelled fumarate increased significantly, whereas changes in ADC values were only detectable 7 days post treatment.
- Authors:
- F Hesse, A Wright, V Somai, F Bulat, K Brindle
- Journal:
- Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition.
- Publication date:
- 22nd Apr 2022
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- DOI