G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

Abstract:

G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding affinity by approximately 1000-fold to give ligands with near micromolar affinity and >40-fold discrimination for quadruplex DNA over duplex.

Authors:

JA Schouten, S Ladame, SJ Mason, MA Cooper, S Balasubramanian

Journal:

J Am Chem Soc

Citation info:

125(19):5594-5595

Publication date:

14th May 2003

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