G-quadruplex recognition by bis-indole carboxamides.
- Abstract:
- Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
- Authors:
- J Dash, PS Shirude, S Balasubramanian
- Journal:
- Chem Commun (Camb)
- Citation info:
- (26):3055-3057
- Publication date:
- 14th Jul 2008
- Full text
- DOI