G-quadruplex recognition by bis-indole carboxamides.

Abstract:

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

Authors:

J Dash, PS Shirude, S Balasubramanian

Journal:

Chem Commun (Camb)

Citation info:

(26):3055-3057

Publication date:

14th Jul 2008

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