G-quadruplex ligands exhibit differential G-tetrad selectivity.

Abstract:

A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.

Authors:

DD Le, M Di Antonio, LKM Chan, S Balasubramanian

Journal:

Chem Commun (Camb)

Citation info:

51(38):8048-8050

Publication date:

11th May 2015

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