Genomic Applications in Epithelial Ovarian Malignancies
- Abstract:
- Recent advances in high-throughput genomic technologies have deepened our understanding of the molecular underpinnings and cell of origin of gynecologic malignancies. Genomic studies of uterine and ovarian cancers have the potential to refine the current classification of these most common gynecologic malignancies and promise the identification of novel prognostic parameters and novel therapeutic targets. Molecular genomic advances could finally alter the so far dismal outcome of patients with advanced epithelial ovarian carcinomas. This chapter reviews key approaches to diagnosis and stratification of epithelial ovarian carcinomas that are now needed to advance the field.