Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

Abstract:

The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.

Authors:

RD Miller, J Hogg, JH Ozaki, D Gell, SP Jackson, R Riblet

Journal:

Proc Natl Acad Sci U S A

Citation info:

92(23):10792-10795

Publication date:

7th Nov 1995

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