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Figure 5 from Deuterium Metabolic Imaging Differentiates Glioblastoma Metabolic Subtypes and Detects Early Response to Chemoradiotherapy

Abstract:
<p>Imaging the effects of chemoradiation on glucose metabolism in tumor models representative of the glycolytic and mitochondrial subtypes. <b>A-D,</b> Representative spectra from voxels within the tumor and normal-appearing brain in 3D <sup>2</sup>H chemical shift images of A11 (<b>A</b> and <b>B</b>) and S2 (<b>C</b> and <b>D</b>) tumor–bearing animals infused with 2 g/kg [6,6-<sup>2</sup>H<sub>2</sub>]glucose before (<b>A</b> and <b>C</b>) and after (<b>B</b> and <b>D</b>) treatment. Fits to the spectra are shown in color: red, water; green, glucose; blue, Glx; and purple, lactate. The tumor is outlined in yellow on the T<sub>2</sub>-weighted <sup>1</sup>H image. The locations of the CSI voxels are indicated by the boxes. The spectra are the sum of six 10-minute spectra acquired from 3 × 3 × 9 mm voxels. Labeled glucose, Glx, and lactate concentrations were determined from summed spectra. <b>E-J,</b> Labeled glucose (<b>E</b>), Glx (<b>F</b>), and lactate (<b>G</b>) concentrations in A11 tumors before and after treatment, and labeled glucose (<b>H</b>), Glx (<b>I</b>), and lactate (<b>J</b>) concentrations in S2 tumors before and after treatment. ns, not significant; *, <i>P</i> < 0.05.</p>
Authors:
JCM Low, J Cao, F Hesse, AJ Wright, A Tsyben, I Alshamleh, R Mair, KM Brindle
Publication date:
14th Jun 2024
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