Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation.

Abstract:

The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel-Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b-i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.

Authors:

RH Scott, C Barnes, U Gerhard, S Balasubramanian

Journal:

Chem Commun (Camb)

Citation info:

(14):1331-1332

Publication date:

1st Aug 1999

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