Exploring a benzyloxyaniline linker utilizing ceric ammonium nitrate (CAN) as a cleavage reagent: solid-phase synthesis of N-unsubstituted beta-lactams and secondary amides.
- Abstract:
- [figure: see text] A novel benzyloxyaniline linker that uses ceric ammonium nitrate (CAN) as a cleavage reagent is described. Its application in the solid-phase synthesis of N-unsubstituted beta-lactams and secondary amides furnishes compounds in moderate to excellent yield (45-91%) and high purity (93-99%).
- Authors:
- KH Gordon, S Balasubramanian
- Journal:
- Org Lett
- Citation info:
- 3(1):53-56
- Publication date:
- 11th Jan 2001
- Full text
- DOI