ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.
- Abstract:
- ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression.
- Authors:
- H Jakobczyk, Y Jiang, L Debaize, B Soubise, S Avner, AA Sérandour, J Rouger-Gaudichon, A-G Rio, JS Carroll, H Raslova, D Gilot, Z Liu, J Demengeot, G Salbert, N Douet-Guilbert, L Corcos, M-D Galibert, V Gandemer, M-B Troadec
- Journal:
- Leukemia
- Citation info:
- 36(2):549-554
- Publication date:
- 1st Feb 2022
- Full text
- DOI