Dynamics of breast cancer relapse reveal molecularly defined late recurring ER-positive subgroups: Results from the METABRIC study
- Abstract:
- Background: Recent studies have demonstrated that women with early stage ER-positive (ER+) and HER2-negative (HER2-) breast cancer have a persistent risk of recurrence and cancer related death up to 20 years post diagnosis, highlighting the chronic nature of ER+ breast cancer and critical need to identify tumor characteristics that are more predictive of risk of recurrence than standard clinical covariates. However, progress in delineating the dynamics of breast cancer relapse and biomarkers of late recurrence has been hindered by the lack of large cohorts with long-term clinical follow-up and molecular information.
- Authors:
- C Curtis, OM Rueda, S-J Sammut, S-F Chin, JL Caswell-Jin, JA Seoane, M Callari, R Batra, B Pereira, A Bruna, HR Ali, E Provenzano, B Liu, M Parisien, C Gillett, S McKinney, A Green, L Murphy, A Purushotham, I Ellis, P Pharoah, C Rueda, S Aparicio, C Caldas
- Journal:
- CANCER RESEARCH
- Citation info:
- 79(4)
- Publication date:
- 1st Feb 2019
- Full text
- DOI