Dynamic modulation of autophagy: implications for aging and cancer.

Abstract:

Reduced autophagy has been implicated in aging, yet whether its loss can promote aging phenotypes and pathologies in mammals, and how reversible this process is, has never been fully explored. Using inducible short hairpin RNA (shRNA) mouse models, we have recently shown that autophagy inhibition accelerates aging, and that even a temporary block in autophagy can create irreversible damage that increases a cancer risk.

Authors:

LD Cassidy, M Narita

Journal:

Mol Cell Oncol

Citation info:

7(4):1754723

Publication date:

1st Aug 2020

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