Dual-sugar imaging using isonitrile and azido-based click chemistries.

Abstract:

We report the first account of metabolically labelling N-acetylglucosamine, in conjunction with either N-acetylgalactosamine or N-acetylmannosamine using a combination of isonitrile- and azide-based chemistries. With the appropriately labelled fluorescent probe molecules, that react with either the azido or isonitrile groups, the method enabled co-visualisation of cancer cell glycoproteins.

Authors:

YA Wainman, AA Neves, S Stairs, H Stöckmann, H Ireland-Zecchini, KM Brindle, FJ Leeper

Journal:

Org Biomol Chem

Citation info:

11(42):7297-7300

Publication date:

14th Nov 2013

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